Technology Home2024-05-19T19:47:58+00:00

Next generation toxicology and drug development instruments

ABOUT THE LOCSENSE ARTEMIS IMPEDANCE/TEER DETECTOR

The Locsense Artemis is an automated, real-time impedance/TEER detector, providing an objective standard for the barrier integrity. Monitor the barrier integrity, while the cell culture is located inside an incubator. The Artemis can be coupled to transwell plates with inserts and microfluidic chips.The Artemis software is intuitive, suitable for first-time users and provides in-depth analysis of impedance measurements.

CUTTING-EDGE 2D AND 3D CELL CULTURE SENSING

Automated endothelial and epithelial barrier assessment of cell cultures in conventional transwell plates with inserts

Locsense Artemis

Artemis

12 wells

10 Hz – 100 kHz

separate smartlid

Locsense Artemis ST closedLocsense Artemis ST

Artemis ST Single Transwell

24 wells

10 Hz – 100 kHz

integrated design

Artemis MT Multi Transwell

4 x 24 wells

10 Hz – 100 kHz

integrated design

CULTURE WARE

Complement with the pre-loaded 24 wells plates with non-rotating inserts

24 well plate transparent

non rotating inserts

transparent PET membranes

24 well plate translucent

non rotating inserts

translucent PET membranes

ARTEMIS 2D AND 3D CELL CULTURE SENSING

FACTSHEETS AND APPLICATION NOTES 

ESSENTIALS ABOUT IMPEDANCE SPECTROSCOPY AND TEER

Electrical impedance spectroscopy: to evaluate and monitor organotypic development and skin barrier function in vitro

Read more

Preprint

Title: Electrical Impedance Spectroscopy Quantifies Skin Barrier Function in Organotypic In Vitro Epidermis Models

Authors: N.J.M. van den Brink, F. Pardow, L.D. Meesters, I. van Vlijmen-Willems, D. Rodijk-Olthuis, H. Niehues, P.A.M. Jansen, S. H. Roelofs, M.G. Brewer, E.H. van den Bogaard and J.P.H. Smits

Read more
Read more

Preprint

Title: The aryl hydrocarbon receptor regulates epidermal differentiation through transient activation of TFAP2A

Authors: Jos P.H. Smits, Jieqiong Qu, Felicitas Pardow, Noa J.M. van den Brink, Diana Rodijk-Olthuis, Ivonne M.J.J. van Vlijmen-Willems, Simon J. van Heeringen, Patrick L.J.M. Zeeuwen, Joost Schalkwijk, Huiqing Zhou, Ellen H. van den Bogaard

Read more
Read more

Article

Title: Advanced pathophysiology mimicking lung models for accelerated drug discovery

Authors: Thanh Huyen Phan, Huaikai Shi Christopher E. Denes, Alexander J. Cole, Yiwei Wang, Yuen Yee Cheng, Daniel Hesselson, Susan H. Roelofs, Graham Gregory Neely, Jun‑Hyeog Jang and Wojciech Chrzanowski

Read more
Read more

Article

Title: Investigations into the FLG Null Phenotype: Showcasing the Methodology for CRISPR/Cas9 editing of human keratinocytes

Authors: Jos P.H. Smits, Noa J.M. van den Brink, Luca D. Meesters, Hadia Hamdaoui, Hanna Niehues, Patrick A.M. Jansen, Ivonne M.J.J. van Vlijmen-Willems, Diana Rodijk-Olthuis, Ce´line Evrard, Yves Poumay, Michel van Geel, Wiljan J.A.J. Hendriks, Joost Schalkwijk, Patrick L.J.M. Zeeuwenand Ellen H. van den Bogaard

Read more
View poster

Poster

Title: Electrical impedance spectroscopy analysis to evaluate organotypic epidermis formation and barrier function in vitro
Authors: Noa J.M. van den Brink, L.D. Meesters, F. Pardow, S. Roelofs, J.P.H. Smits and E.H. van den Bogaard
View poster
View poster

Poster

Title: Developing a scalable hiPSC-derived blood-brain barrier model

Authors: Robin Pampiermole, Sandro Meucci, Ruud Das, Juda-El Sam, Tim Segers, Loes Segerink, Kerensa Broersen, Andries van der Meer

View poster
View poster

Poster

Title: Retina-on-Chip: Modeling and treating eye diseases in a dish

Authors: Edwin van Oosten, Devin Veerman, Stijn Berendsen, Rob Collin, Dirk Lefeber, Loes Segerink, Seba Almedawar, Jürgen Prestle, Parth Patel, Susan Roelofs, Stefan G. Kauschke, Andries van der Meer, Alejandro Garanto

View poster
Read more

White paper

Title: Guardians of the gateway: Exploring the blood-brain-barrier with impedance spectroscopy
Author: E. Geervliet, R. Pampiermole, S.H. Roelofs
Read more
Read more

White paper

Title: Beyond the Barriers: Impedance-based quality control of in vitro lung models

Authors: E. Geervliet, S.H. Roelofs

Read more

LOCSENSE, TRUSTED PARTNER IN CELL BIOLOGY

The Artemis is unique in it’s smart workflow, sensitivity and flexibility. Locsense provides a total solution for quantitative cellular barrier measurements. Demonstrated e.g. for 3D skin constructs, gut tissue and cardiomyocytes.

ABOUT LOCSENSE

Locsense was founded in 2016 in Enschede and is revolutionizing how we monitor, measure, and test cells right from the lab bench, offering a cruelty-free alternative to animal testing. Our flagship device, the Locsense Artemis, is a non-invasive sensor that monitors cell health, enabling groundbreaking discoveries in fields like cosmetics, pharmaceuticals and the food industry.

Locsense is at the forefront of lab technology with devices that non-invasively monitor and test cells outside the body. In our bodies, cells often form protective barriers. Think of these barriers as tiny walls that separate different areas. For example, the lining of your gut has cells that create a barrier between your food and the rest of your body, or the skin which forms a protective barrier for influences from outside.

Impedance measurements offer a way to measure how strong these barriers are and whether they are intact. The Artemis offers insight into how healthy cell barriers are. This is crucial for drug testing, studying diseases, and making sure our body’s defenses work properly.

Our products are designed to combine with conventional workflow. At the same time they can be coupled to innovative in-vitro cell culture platforms, such as microfluidic chips, organs-on-chip or smartplates.

Susan Roelofs
Susan RoelofsCEO and founder
Eline Geervliet
Eline GeervlietApplication Scientist
Parth Patel
Parth PatelElectrical engineer
Erwin de Vries
Erwin de VriesSoftware engineer
Attie Hendriks
Attie HendriksElectrical engineer
Jorg Gortemaker
Jorg GortemakerData scientist
Navin Reddy
Navin ReddySoftware engineer

Get Hands On With Locsense Technology

VACANCIES

IN THE NEWS TODAY

Follow us to stay up to date with the latest developments and news

CONTACT LOCSENSE TODAY

Contact us if you have any questiones regarding our products and services.

Follow Locsense On Social Media

 

LOCSENSE B.V.

Visiting address:

Institutenweg 25
7521 PH Enschede

Phone: +31(0)6-10499335

Email: info@locsense.nl
Web: www.locsense.nl

Ga naar de bovenkant