Technology Home2024-09-28T19:27:07+00:00

Next generation toxicology and drug development instruments

ABOUT THE LOCSENSE ARTEMIS IMPEDANCE/TEER DETECTOR

The Locsense Artemis is an automated, real-time impedance/TEER detector, providing an objective standard for the barrier integrity. Monitor the barrier integrity, while the cell culture is located inside an incubator. The Artemis can be coupled to transwell plates with inserts and microfluidic chips.The Artemis software is intuitive, suitable for first-time users and provides in-depth analysis of impedance measurements.

CUTTING-EDGE 2D AND 3D CELL CULTURE SENSING

Automated endothelial and epithelial barrier assessment of cell cultures in conventional transwell plates with inserts

CE and UL certified

Locsense Artemis

Artemis

12 wells

10 Hz – 100 kHz

separate smartlid

Locsense Artemis ST closedLocsense Artemis ST

Artemis ST Single Transwell

24 wells

10 Hz – 100 kHz

integrated design

Artemis MT Multi Transwell

4 x 24 wells

10 Hz – 100 kHz

integrated design

CULTURE WARE

Complement with the pre-loaded 24 wells plates with non-rotating inserts

24 well plate transparent

non rotating inserts

transparent PET membranes

24 well plate translucent

non rotating inserts

translucent PET membranes

ARTEMIS 2D AND 3D CELL CULTURE SENSING

FACTSHEETS AND APPLICATION NOTES 

ESSENTIALS ABOUT IMPEDANCE SPECTROSCOPY AND TEER

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Webinar

Title: Does all disease begin in the gut

Presenter: Eline Geervliet

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Article

Title: CLDN1 knock out keratinocytes as a model to investigate multiple skin disorders

Authors: Kimberly A. Arnold, Mary C. Moran, Huishan Shi, Ivonne M. J. J. van Vlijmen-Willems, Diana Rodijk-Olthuis, Jos P. H. Smits, Matthew G. Brewer

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Preprint

Title: Electrical Impedance Spectroscopy Quantifies Skin Barrier Function in Organotypic In Vitro Epidermis Models

Authors: N.J.M. van den Brink, F. Pardow, L.D. Meesters, I. van Vlijmen-Willems, D. Rodijk-Olthuis, H. Niehues, P.A.M. Jansen, S. H. Roelofs, M.G. Brewer, E.H. van den Bogaard and J.P.H. Smits

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Preprint

Title: The aryl hydrocarbon receptor regulates epidermal differentiation through transient activation of TFAP2A

Authors: Jos P.H. Smits, Jieqiong Qu, Felicitas Pardow, Noa J.M. van den Brink, Diana Rodijk-Olthuis, Ivonne M.J.J. van Vlijmen-Willems, Simon J. van Heeringen, Patrick L.J.M. Zeeuwen, Joost Schalkwijk, Huiqing Zhou, Ellen H. van den Bogaard

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Article

Title: Advanced pathophysiology mimicking lung models for accelerated drug discovery

Authors: Thanh Huyen Phan, Huaikai Shi Christopher E. Denes, Alexander J. Cole, Yiwei Wang, Yuen Yee Cheng, Daniel Hesselson, Susan H. Roelofs, Graham Gregory Neely, Jun‑Hyeog Jang and Wojciech Chrzanowski

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Article

Title: Investigations into the FLG Null Phenotype: Showcasing the Methodology for CRISPR/Cas9 editing of human keratinocytes

Authors: Jos P.H. Smits, Noa J.M. van den Brink, Luca D. Meesters, Hadia Hamdaoui, Hanna Niehues, Patrick A.M. Jansen, Ivonne M.J.J. van Vlijmen-Willems, Diana Rodijk-Olthuis, Ce´line Evrard, Yves Poumay, Michel van Geel, Wiljan J.A.J. Hendriks, Joost Schalkwijk, Patrick L.J.M. Zeeuwenand Ellen H. van den Bogaard

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Poster

Title: Breathing life into innovation: Developing an advanced COPD lung model for therapeutic discovery

Authors: T.H. Phan, H. Shi, C.E. Denes, A.J. Cole, Y. Wang, E. Geervliet, Y.Y. Cheng, D. Hesselson, S.H. Roelofs, G.G. Neely, J.Jang and W.Chrzanowski

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Poster

Title: Electrical impedance spectroscopy analysis to evaluate organotypic epidermis formation and barrier function in vitro
Authors: Noa J.M. van den Brink, L.D. Meesters, F. Pardow, S. Roelofs, J.P.H. Smits and E.H. van den Bogaard
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Poster

Title: Developing a scalable hiPSC-derived blood-brain barrier model

Authors: Robin Pampiermole, Sandro Meucci, Ruud Das, Juda-El Sam, Tim Segers, Loes Segerink, Kerensa Broersen, Andries van der Meer

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Poster

Title: Retina-on-Chip: Modeling and treating eye diseases in a dish

Authors: Edwin van Oosten, Devin Veerman, Stijn Berendsen, Rob Collin, Dirk Lefeber, Loes Segerink, Seba Almedawar, JĂźrgen Prestle, Parth Patel, Susan Roelofs, Stefan G. Kauschke, Andries van der Meer, Alejandro Garanto

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White paper

Title: Guardians of the gateway: Exploring the blood-brain-barrier with impedance spectroscopy
Author: E. Geervliet, R. Pampiermole, S.H. Roelofs
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White paper

Title: Beyond the Barriers: Impedance-based quality control of in vitro lung models

Authors: E. Geervliet, S.H. Roelofs

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LOCSENSE, TRUSTED PARTNER IN CELL BIOLOGY

WHAT CLIENTS SAY ABOUT US

The Artemis has become an essential piece of technology in a majority of the experimental and quality control workflows in our laboratory. This system has enabled us to establish reliable, rapid and cost-effective methodologies to assess bioelectrical parameters of cells and tissues.

This advancement has sped up our development of sophisticated human-like organ and tissue models. The Artemis is now a key tool for testing the quality of these models and assessing the safety of nanoparticles (such as air pollutants), as well as the safety and efficacy of new therapeutics (like extracellular vesicles) for repairing various organs.

Additionally, using the Artemis has significantly reduced the number of tests needed to evaluate the models and decreased the use of plasticware in the lab, contributing to the sustainability of our research. Lastly, the Locsense team has provided exceptional support with experimental setup and data analysis.

Prof. Wojciech Chrzanowski, The University of Sydney | Faculty of Medicine and Health

THEY TRUST US

ABOUT LOCSENSE

Locsense was founded in 2016 in Enschede and is revolutionizing how we monitor, measure, and test cells right from the lab bench, offering a cruelty-free alternative to animal testing. Our flagship device, the Locsense Artemis, is a non-invasive sensor that monitors cell health, enabling groundbreaking discoveries in fields like cosmetics, pharmaceuticals and the food industry.

Locsense is at the forefront of lab technology with devices that non-invasively monitor and test cells outside the body. In our bodies, cells often form protective barriers. Think of these barriers as tiny walls that separate different areas. For example, the lining of your gut has cells that create a barrier between your food and the rest of your body, or the skin which forms a protective barrier for influences from outside.

Impedance measurements offer a way to measure how strong these barriers are and whether they are intact. The Artemis offers insight into how healthy cell barriers are. This is crucial for drug testing, studying diseases, and making sure our body’s defenses work properly.

Our products are designed to combine with conventional workflow. At the same time they can be coupled to innovative in-vitro cell culture platforms, such as microfluidic chips, organs-on-chip or smartplates.

Susan Roelofs
Susan RoelofsCEO and founder
Eline Geervliet
Eline GeervlietApplication Scientist
Parth Patel
Parth PatelElectrical engineer
Erwin de Vries
Erwin de VriesSoftware engineer
Attie Hendriks
Attie HendriksElectrical engineer
Jorg Gortemaker
Jorg GortemakerData scientist
Navin Reddy
Navin ReddySoftware engineer

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IN THE NEWS TODAY

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Decoding Skin Resilience

juni 19th, 2024|

Researchers from the Radboudumc and Locsense developed an approach to measure how genetic variants, inflammatory mediators, and drug candidates affect skin barrier development and [...]

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LOCSENSE B.V.

Visiting address:

Institutenweg 25
7521 PH Enschede

Phone: +31(0)6-10499335

Email: info@locsense.nl
Web: www.locsense.nl

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